The Overdose Epidemic - Zeroing in on Xylazine On-Demand-The Overdose Epidemic

Video Transcription

Video Summary

In this video transcript, Dr. Melody Isgro discusses the presence of xylozine, an alpha-2 agonist, in the drug supply. Xylozine is often combined with fentanyl to extend the duration of the high. However, it has been linked to overdoses, dependence, and addiction. Xylozine is primarily found in the Northeast, particularly in Pennsylvania, but its use is increasing across the country. Xylozine testing is challenging due to its rapid elimination from the body, although point-of-care testing is available. The video also explores the use of xylazine in the illicit drug supply, its effects, and risks. Chronic use of xylazine can lead to dependence and withdrawal symptoms, which can be severe and similar to those seen with opioids. The treatment for xylazine withdrawal includes managing both opioid and xylazine-specific symptoms with medications like benzodiazepines and alpha-2 agonists. Xylazine wounds, which are unique and distinct, can occur regardless of the route of administration and may require intensive wound management. The video emphasizes harm reduction strategies such as using test strips to identify xylazine in the drug supply, safer injection techniques, and carrying naloxone for overdose prevention. Ongoing monitoring and support for individuals who use drugs, especially in areas where xylazine is prevalent, are crucial.

Keywords

xylozine

alpha-2 agonist

drug supply

fentanyl

overdoses

dependence

addiction

xylazine

illicit drug supply

harm reduction strategies