PCSS MAT Half and Half Training 2021-2022-Module 6: Neurobiology

Module 6: Neurobiology
Pdf Summary
This document is a summary of a training module on waiver eligibility related to opioids. The training module focuses on various topics, including the neurobiology of opioids, the effects of opioids on the brain, the role of opioid receptors, and the physiological effects of opioids.<br /><br />The document begins by highlighting the objectives of the training module, which include describing the physiological effects of opioids and the receptors involved, understanding the effects of opioids on the brain's reinforcement pathways, and recognizing manifestations of opioid tolerance, intoxication, overdose, and withdrawal.<br /><br />The document provides definitions of terms related to opioids and highlights that the term "opioid" refers to a wide range of substances, including opiates, derived compounds, and natural and synthetic analogs.<br /><br />It then goes on to discuss the neurobiology of opioids, including the different types of opioid receptors and their locations in the central nervous system, peripheral nerves, gut, and immune system cells. The main focus is on the mu receptors, which are responsible for the clinically significant effects of opioids.<br /><br />The document also discusses the physiological effects of opioids, which include analgesia, sedation, euphoria, pupil constriction, decreased respiration and heart rate, and nausea. It also highlights the effects of opioids on the gut and peripheral tissues.<br /><br />The training module further explores the effects of opioids on the positive and negative reinforcement pathways of the brain and the role of agonists, antagonists, and partial agonists on the mu receptor. It explains how buprenorphine, a partial agonist, can prevent withdrawal symptoms and maintain a steady level of opioid activity.<br /><br />The document also covers topics such as opioid tolerance, intoxication, overdose, and withdrawal, providing information on the signs, symptoms, and timing of these conditions. It discusses the use of medications like naloxone and buprenorphine in the treatment of opioid overdose and withdrawal.<br /><br />In summary, the training module provides an overview of the neurobiology of opioids, their physiological effects, and the management of opioid tolerance, intoxication, overdose, and withdrawal.
Keywords
waiver eligibility
opioids
neurobiology
physiological effects
reinforcement pathways
opioid tolerance
overdose
withdrawal
mu receptors
buprenorphine