PCSS Half and Half MAT Waiver Training 2021-2022-Module 1: Neurobiology

Module 1: Neurobiology

Pdf Summary

This document provides training on waiver eligibility for opioids. The objectives of the training are to describe the physiologic effects of opioids and the receptors involved, the effects of opioids on the positive and negative reinforcement pathways of the brain, the effects of Agonists, Antagonists, and Partial Agonists on the mu receptor, and the manifestations of opioid tolerance, intoxication, overdose, and withdrawal. <br /><br />The document explains that humans have three types of opioid receptors, with the main target being the mu receptors. Opioids have various effects on the body, including analgesia, sedation, euphoria, pupil constriction, decreased respiration, and decreased heart rate. They can also cause constipation and modulate inflammatory responses. Opioids act on receptors in the brain regions associated with pain perception, reward pathways, and respiratory function.<br /><br />The training covers the neurobiology of reinforcement, imaging of addiction, vulnerability to substance use disorders, and the biology of reinforcement. It also discusses the pharmacology of opioid ligands and the use of opioids in therapy, including partial agonists like buprenorphine and antagonists like naltrexone.<br /><br />The document explains the concepts of precipitated withdrawal, opioid overdose, and opioid withdrawal. It describes the signs and symptoms of these conditions and the appropriate treatments, including the use of naloxone for overdose reversal. The management of opioid withdrawal can involve symptomatic treatment or the use of medications such as methadone or buprenorphine.<br /><br />In summary, this training provides comprehensive information on the neurobiology of opioids, their effects on the brain, and the manifestations of tolerance, intoxication, overdose, and withdrawal. It also discusses the use of different medications in opioid therapy and the management of withdrawal symptoms.

Keywords

waiver eligibility

opioids

receptors

intoxication

overdose

withdrawal

partial agonists

antagonists

neurobiology

management