Medical Student 8 Hour Buprenorphine Training-Session 2: Neurobiology

Video Transcription

Video Summary

In this video, Dr. James Finch presents Module 2, Neurobiology of Opioid Use Disorders. He begins by referring back to Module 1 and introducing Bruce, a 40-year-old attorney and father who wants help for his heroin addiction. Dr. Finch explains that opioids, whether natural or synthetic, react with the body's opioid receptors, including the mu, kappa, and delta receptors. The mu receptor is most relevant to the effects of opioids. Opioids affect various areas of the brain, including the thalamus and ventral tegmental area, which release dopamine and contribute to pleasure and reward. Dr. Finch also discusses the physiological effects of opioids, such as relief of pain, sedation, and slowed respiration. He explains how Bruce's brain changes with chronic opioid use, including decreased dopamine release and increased amygdala reactivity. Dr. Finch also discusses genetic and environmental factors that contribute to vulnerability to addiction. He explains the difference between full agonist, partial agonist, and opioid antagonist medications, and the use of buprenorphine and naloxone in treatment. The video concludes with information on opioid withdrawal symptoms and treatment options.

Keywords

Neurobiology

Opioid Use Disorders

Opioid Receptors

Brain Effects

Chronic Opioid Use

Treatment Options