AOAAM Enduring Half and Half Waiver Training 2022-Module 1: Neurobiology

Module 1: Neurobiology

Pdf Summary

This document summarizes Module 1 of a waiver eligibility training session on neurobiology for opioids. The objectives of the training include describing the physiological effects of opioids, the effects of opioids on the brain's reinforcement pathways, the effects of various opioid medications on the mu receptor, and recognizing the manifestations of opioid tolerance, intoxication, overdose, and withdrawal. <br /><br />The document explains that humans have three types of opioid receptors, with the mu receptor being the main target for opioids. Activation of mu receptors in the central nervous system causes effects such as analgesia, sedation, euphoria, and decreased respiration. Opioid receptors are widely distributed throughout the brain, spinal cord, gut, and peripheral regions. The document also discusses the binding of opioids to different areas of the brain and the physiological effects that result.<br /><br />The document provides information on the different types of opioid medications, including agonists, antagonists, and partial agonists, and how they interact with the mu receptor. It explains that partial agonist medications like buprenorphine can prevent withdrawal and maintain a steady level of opioid activity without leading to fatal respiratory suppression. It also discusses the concept of precipitated withdrawal, which can occur when a partial agonist displaces other agonists.<br /><br />The document further addresses the topics of opioid tolerance, intoxication, overdose, and withdrawal. It describes the signs, symptoms, and timing of these conditions and provides information on their management and treatment. The document emphasizes the importance of a comprehensive approach to addressing opioid addiction that includes medication-assisted treatment (MAT) and the use of medications like naloxone to reverse opioid overdoses.<br /><br />In summary, the document provides an overview of the physiological effects of opioids, the role of the mu receptor in opioid action, the different types of opioid medications, and the manifestations and management of opioid tolerance, intoxication, overdose, and withdrawal.

Keywords

mu receptor

opioid medications

opioid tolerance

intoxication

overdose

withdrawal

physiological effects

brain areas

precipitated withdrawal

medication-assisted treatment